The aim of this study was to predict anxiety (Covid disease 19) based on the psychological flexibility of female employees of Karaj Health Department. Undoubtedly, one of the most important of these factors is anxiety related to coronary heart disease. Research shows that diseases such as respiratory diseases can cause anxiety due to serious physical problems and reduced quality of life of patients. These factors can range from symptoms to serious clinical disorders. Increased feelings of loneliness, decreased social support, decreased life expectancy, and feelings of fear and anxiety to clinical stress and anxiety, obsessive-compulsive disorder, and even signs of post-traumatic stress have been seen in similar situations. The research was simple random sampling. The research instrument was a standard questionnaire including coronavirus anxiety questionnaire, zero resilience psychological resilience questionnaire and colleagues. Descriptive and inferential statistics have been used to analyze the data. Research findings show that psychological resilience can explain about 3.5% of changes in Covid 19 anxiety. Thus, the research hypothesis that Covid's anxiety is predicted based on psychological flexibility was confirmed. Conclusion: Female employees of Karaj Health Department who had high cognitive flexibility were able to adapt to coronary anxiety.